Whether it's to be manned or unmanned fighters may have been settled.
http://security.blogs.cnn.com/2012/06/13/sources-flight-suit-could-be-cause-of-oxygen-loss-in-f-22-flights/?hpt=hp_t2
It's looking as if Man cannot take the stresses of future fighters even with aid. The hypoxia problem caused by flying F-22 Raptors may not have a quick fix, and certainly would get worse with even higher performance machines.