Coriolis Force is not an issue if you make the centrifuge radius large enough and the rotation speed slow enough. A dumbbell-shaped ship with facilities at either end, connected by a truss or tether system and spun about its center of gravity, would be the simplest form and would work. The Discovery centrifuge shown in "2001: A Space Odyssey" would be too small, and would have problems with Coriolis disorientation.

Balance can be accomplished by moving weights or liquids back and forth along the connection system. This argues in favor of a rigid trusswork connecting the spinning elements instead of tethers. Although the tethers would be much lighter, and require much less assembly in space, a trusswork would be more dynamically stable (especially if thrust were applied in emergencies) and allow structures and equipment to be mounted on it, including the balancing systems and some mechanism to allow travel between the two ends.