I love Despair.com
My wife is looking for some artwork to decorate her newly expanded medical office. I'm trying to convince her that some of these posters would make great decorations. Most medical offices are rather dull places. Why not put up decorations that'll give people a much needed laugh? Of course, this may be why she doesn't let me decorate our house...
Some of my favorites include:
Ambition
Nepotism (probably hits too close to home for her office...)
Success
Individuality
Delusions
Idiocy (this one really reminds me of the DNC)
Agony (probably not the best choice for a pain treatment center, but I use it as wallpaper on my computer at work)
Consulting