Perhaps it has already happened, many times.
In civilizations scattered throughout the universe, the inevitable, unavoidable, suicidal discovery has been stumbled onto many times, and the spheres of oblivion are expanding at the speed of light into the cosmos. And we will never know it, we will have no way of knowing it, until the horizon of death sweeps over us.
But even though the ability to destroy the universe is only an idle speculation, the ability to destroy our own little piece of it is not. And super science will not be necessary to do it.