We need to start a massive research effort to design life to live for extended times in space without the technology. Cause its the technology that breaks down.

Step 0: Establish a space-survival genomics research initiative, with special exclusions from bioethics regulations (not all, but perhaps some - trying to learn something here).

Step 1: Create a photosynthetic mouse. Try it. See if it results in a decreased infrastructure requirement for space habitation.

Step 2: Create a photosynthetic chimp.

Step 3: Try other modifications for heat management.

Step 4: Find protein synthesis pathways that can use a nuclear thermal battery as an energy source.

Step 5: Survival in a vacuum.

Step 6: Bioelectric radio signaling

Step 7: Chromataphor visual communication

Step 8: Direct chromataphor electric machine interface

Step 9: Optical polarization biosensors

Step 10: Biological optical interferometers

... and on up the evolutionary ladder. Per Ardua Ad Astra (through adversity to the stars).