At least I don't think so- we are talking about effects that show up on the Plank scale...

However, one implication of a simulation concept is that space-time itself would be quantized. Coincidentally (?) one of the leading theories of quantum gravity (Loop Quantum Gravity) requires quantization of space time.

IF spacetime is quantized, then it may have effects on short wavelength light travelling cosmological distances - efforts to see these effects have been, so far, unsuccessful.

I am not saying it IS a simulation run by an extradimensional kid on his extradimensional PC, while he drinks extradimensional Red Bull and is yelled at by his exasperated extra-dimensional mother to do his chores... I am just saying that it may effectively have many of the constraints such a simulation would have- we already see more than a few things that lend themselves to that interpretation.

I have long thought that it might bear fruit for theorists to approach physics from that viewpoint...

Perhaps magic mushrooms will fall under 'research supplies' in the near future... And more published papers will start with 'Whoah, dude- check this out, what if...' :)