I'm wondering if the CEV will dock to the ISS.
It's going to be flying with a crew some time after the last Shuttle returns back from ISS.
The Shuttle-ISS docking mechanism is too big for a small spacecraft like the CEV, unless the CEV becomes so big and expensive it will need its own ELV and that would reduce hopes in going soon any further than LEO.
This means the CEV would have to adopt the Russian docking mechanism (thereby relying on Russian technology and forcing some technology transfer that is apparently forbidden by law).

Unless, of course, it is decided that the CEV won't go to the ISS, as perhaps the Soyuzes, Progresses and ATVs are good enough.
I wonder if the CEV will have different designs according to the missions or be frozen with one polyvalent design.
I can't imagine NASA completely dropping the ISS and letting the world take care of it. If there's a contingency involving a US module, NASA will have to get involved.

But it's true the ISS is in the wrong orbit for anything above LEO, so another platform might become necessary if an Earth-Orbit rendez-vous mode is prefered for interplanetary flights.

However, I'm not sure the KSC is the most ideally located spaceport (28 degrees).
For instance: The Moon's orbit around the Earth is 5.09 degrees north and south of the equator.
Kourou's location in French Guyana is 5.3 degrees north of the equator.

Doesn't it make Kourou an even better launch place for the Moon?

There are plans to allow the Russians to launch their Soyuz rocket from Kourou (not yet manned, but...).

Raoul