The view in the rendering is due west, or near enough as makes no difference. The building is superimposed on a genuine photograph; the twilight effect is almost certainly also computer-generated.

The moon is, as you say, waaaay too far north for Chicago's latitude. It is also the wrong phase to be seen in the western sky at evening twilight (it should be a waxing crescent, not a waning gibbous approaching last quarter).

Useless factoid: Since you've recognized the Sears Tower in the left background, look to it's left, in the foreground. That's the Prudential Building -- once Chicago's tallest, until the Hancock was built (tallest building on the right hand part of the picture).