that depends on your definition of the word "large". Conceivably, we could build a really large capsule for such payloads. The question is why should we?

Do we need to send humans to space to launch payloads? Most of space history suggests we don't. The Russians have launched payloads for almost 48 years without needing to send humans. These payloads include space station modules, although those required their own propulsion and navigation systems. Even the Shuttle has been somewhat limited in carrying payloads since the Challenger accident.

There hasn't been a lot of need to return payloads from space other than things like film canisters, research payloads, etc. Part of the reason is that launch costs are so high as to make returning payloads prohibitively expensive. The same applies to most examples of servicing payloads in space but that could change with robotic service vehicles and/or manned vehicles that don't cost so much to fly.