If the universe weren't biofriendly, we wouldn't have evolved. And just because we have evolved doesn't mean the universe will support further evolution. We're already aware of serious limitations to our endeavours.

I believe the 4-dimensional universe that we observe arose from an extreme high energy collision between 5+ dimensional sub-Planke-scale particles. The resulting particle shower expanded and decayed into stable structures that we see today. With constant mass it is all gravitationally bound inside an event horizon roughly 170 billion lightyears in diameter. Due to lightspeed delay, we are still able to observe this expansion today at large cosmic distances, which is like seeing how things were billions of years ago. The properties of our lower dimensional universe were probably determined by the species of higher dimensional particles that collided. Ergo, if a universe arose from a different type of collision it might not support life.

How things will go in the future are not known. I suspect that black holes will occasionally grow large enough to undergo "flashover", an exponential and superluminal increase in size, consuming everything, recycling all complex matter within a large region of space back into simple forms in a never-ending random cycle. The before and after images of such a flashover event might be a Blazar, a black hole with tens or hundreds of billions of solar masses, suddenly disappearing in an poof and leaving a large multi-galactic mass cloud of hydrogen and helium in its place.