Fermi's paradox wasn't the inexcapable result of some statistical physical calculation or fundamental theorem. It was a question posed during a meal with fellow Los Alamos physicists as a continuation of an earlier discussion.

"Where are they?"

It was the observation that if the galaxy is teeming with life, they should be lisiting Earth and detectable via radio comunication and broadcast.

Fermi was a smart physicist, a little too ahead of his times as he probably died as a result of cancer from exposure to his experiment, the fission reactor at U of Chicago. But his treatment of this subject was not all that sophisticated. More realistic possibilities have been proposed in the 50 some years since but still Fermi's "paradox" endures.

Assuming we dont destroy ourselves in the annihilation of extremist anti-ethoses(or whatever is plural for ethos), we could find through scientific and technical advances that there is an inner space accessable, richer than all of external reality and that expanding into the solar system, much less the galaxy isn't so exciting after all.

And if astrophysical disaster sprouts it's ugly head before we become 'gods' of matter and energy and after we become proficient in spacefaring, a good place for the unaugmented human to hide from a tsunami of high energy particles may be the atmosphere of Saturn, our local storm shelter.