Interesting question
I fully expect them to be used.
I also fully expect the news media and liberal schoolarly types to argue ad nausiam that they are immoral weapons of mass destruction.
I do not expect nuclear weapons to be used. The precedent would be disasterous and would likely come back to haunt us at some point. The nuclear option will not be ruled out publicly, but they will not be used unless a doomsday senario erupts. That will be up to our enemies: How far are they willing to go?