He could be reliably located, hiding out in a mile-long tunnel, under some
two mile-high mountain in Afghanistan.
He could have a year's supply of food, ammo, & water. Not to mention hundreds
of heavily-armed guards.

"Smoke him out"?

Not even a fuel-air bomb, nor a ground-penetrating "bunker-buster" may do the job.

You can bet that that tunnel would
have heavily sandbagged entrances,
and even reinforced steel-doors.
[scratch the idea of cruise missiles
plunging through the tunnel entrances]...

That leaves three choices.

(1) Do an Iwo Jima [Using your Army Corps of Engineers to patiently use
hundreds of tons of conventional-explosives to rip away
at the mountain and the tunnel defences and obstacles, while Army paratroopers
and leathernecks resort to using more modern versions of flamethrowers and
Bangalore-torpedoes.] with expected
heavy casualties for all sides.

[2] Lay seige to the tunnel, patiently
wait a year or two while he starves,
and while the besieging forces defend against perimeter attacks made against them.

(3) nukes.

Jacob