Saturn V lifted 118 tonnes to LEO and 47 Tonnes after TLI to the Moon.
The Shuttle weighs about 120 tonnes in LEO with included up to 20 tonnes on cargo.
Can this be suitable to send a crew to the Moon and back?

Apparently it will need to be refueled on the Moon and there are no paintings showing what part of the lander actually lifts off from the Moon, so there's a problem if it depends on refueling from the Moon (for the first flights at least when it won't be available).

If going back to the Moon means docking with a platform in a Moon polar orbit, the launch window from Earth will have to be extremely precise!!!!! We have never docked with a spacecraft in orbit around another world, when COMING from outside of that world! Besides, it should then be a Moon Polar orbit which makes it even more difficult!!
And besides, if the way to land on the Moon has been left in Moon Polar Orbit from a previous expedition, what about the consumables that vaporize with time or are used? Such a Moonlander will have to get its fuel from somewhere and if it's the Earth, we're back with the problem I hereabove mentioned! If it's the Moon, all the infrastructure must already be in place and that's unlikely for the first expeditions
Wouldn't it be preferable to build a Heavy Lift Launch Vehicle capable of sending a crew to the surface of the Moon and back from it, without docking with another spacecraft, and use the same kind of rocket for later Mars expeditions?
It's a matter of finding what is the right kind of LEO payload capacity it must have and then do all those things without depending on external conditions such as refueling on the Moon and/or Lunar orbit Rendez-vous; those things can certainly come later once there is an operational base and LOX is extracted from the soil but it can't be done for the first crews.

Raoul