When they were doing space station designs in architecture school, a lot of people got very "clever," combining several local "down" directions in one room, like something Escher would have done.

As I learned more over time, and looked up research, I found that people in microgravity really LIKE having a definite signal in the room as to which way is "up." Different colored floors and ceilings, lights only in the ceiling, rooms that try to keep a consistent direction as you move through the station. Otherwise, disorientation, or worse.

I wonder if people who were born and raised in zero-G would adapt better to "3-D" living.