There are so many reasons it won't work.
Yes, you can grow food indoors, but in terms of sustainability.... what is best is really the surface of a planet.
To live sustainably in space would require unimaginable forms of evolution that eliminate the technology needed to sustain life in space.
The future is really in reproductive technology. The ethical constraints have to be relaxed, and alot of social development has to take place before that will happen. And how do we decide which biological traits to enhance? How can we know?
We can't.
The future is unknown.