FTL
My own jargon for star travel is Faster Than Life.
I don't think we will ever overcome the limitations of e=mc2 but I do believe we will extend the human life span to the point that it will change the nature of time as we perceive it. Relativity become relative if we stop dying so fast.
Alway the possibility of new science to warp space or something but extending life indefinitely is more attainable imo