Re: Drugs and the meaning of life
"If the doors of perception were cleansed every thing would appear to man as it is, infinite. For man has closed himself up, till he sees all things through narrow chinks of his cavern."
William Blake, The Marriage of Heaven and Hell, 1793.
For a far more more extended thesis, see Andrew Weil's The Natural Mind.
There is a lot of current research into these drugs and the treatment of PTSD and other emotional disorders, with interesting results. Irrational fear has thwarted this reseach for decades.
I was in college when I had my own experience in this realm. And it was both profound and transformative. But not a path to be tread lightly or repeatedly.