If it is indeed in the genes, then of course the genes would need to change to get a changed condition.
And the genes have not changed much in ten of thousands of years [at least].

But most people are aware that this is NOT in the genes- that much of what is human is software rather than hardware. Though there is a marked differences in the genes between male and female.

Humans are predators- a very dangerous predator.
But I don't see it as solving anything if humans were somehow herbivorous or prey animals. It's not a matter of what you eat- house cat [predator] isn't worse in this regard than say, a rabbit.
Instead this is more about social behavior of a group. And herbivorous or prey animal don't seem to me have anything particularly outstanding regarding in their social behavior.

What makes a human a very dangerous predator is it's ability to function in and as a group- the individual without the software or just considering it's hardware is not a dangerous predator- more of a wonder that it can survive at all.

In terms social behavior and ability, the human for tens of thousands of years has been a very sophisticated creature as compared any other creature or primate.

And if it was merely about room and resources, then space solves this problem in spades.
But whole idea that we currently lack room or resources on Earth is, in my opinion, nonsense.
If you compare America with Europe or Asia, America is under populated. Russia is under populated. Canada is obviously under populated- the largest countries in the world are under populated. And we have more than 2/3 of planet as oceans and these have no humans populations.

The only limiting factor in terms of resources is energy- and more specifically, cheap energy.
Expensive energy is everywhere- it's 3 miles below your feet anywhere on this planet, for example.

Any shortage of cheap energy on this planet is mostly a problem created by humans rather than the nature of planet earth.
The difficulties of getting enough cheap energy is the same as the problem of getting enough food for people- it's not due to there being too many people living in one area or the potential of this planet providing enough food.

As far as egos and competition. One can have all kinds of things which one can be competitive concerning. It could be home run per season. It could be who writes the best poetry or song.
Murderers may have ego problems, they could be competitive. But I would say instead it's the lack of ego and lack of ability to be competitive in general which is more of factor.

Competition is about following the rules. No one thinks someone is better basketball player if they shoot the best basketball player with a gun.

If you trying get to a hospital in a emergency, you may run red lights and you may exceed the speed limit. In a competitive environment, people will have tendency to take shortcuts and bend or break rules. And if one is in an environment where most people are bending or breaking rules, people will be even more "reckless" in regard to any rules. And then when the people who make rules and those enforcing the rules are breaking the rules it's worse than when the other people breaking rules.

"Unless there's a frequent rotation to the base and residence in the colony is regarded as a privilege it's not going to work. It's in the genes. And egos."

I don't understand your point about "frequent rotation to base and residence"

And want to take another whack, regarding "egos".
The Japanese have tendency due to their culture to "suppress" their egos. Or one could say there is a marked difference between the Japanese and American way of interacting socially.
Would you assume that the Japanese or some other culture would have less of a problem in this regard- is there some specific human culture which would be less dangerous to earthlings if they were in space?