Not At All - The Lesson Is Don't Depend on A Closed System
Go to the Moon and you need a Biosphere 2 or a lot of shipments from Earth. Go to Mars and you can replessih your H2O, carbon, nitrogen, and O2 (through electrolysis) supplies at will. Biosphere 2 was a failure, but not a miserable failure that needed much more than a small input of fresh supplies. There was a tremendous amount of engineering that came close to being self sustaining.
Regards,
Mark
