No. It detects physical reactions associated with willfully and knowingly making false statements
There is a huge difference, and it's why lie detectors are little more than junk science, and why they aren't, nor should ever be, admissable in court.
If I'm a good enough actor, or if I'm a delusional Loony Bin type, or if I'm fanatical enough in my beliefs to think my false statements are a justifiable means to an end, I'll pass a lie detector test with flyng colors, no matter how outlandish my statements.