"Is nothing sacred?" Not to Matt and Trey
I haven't seen anything they consider to be above nailing to the floor. With lots of nails. This irritates a lot of people on both the Left and the Right, but it's funnier when it comes from the Left, which widely advertises it's open-mindness and enthusiasm for being outrageous.
"South Park" has the amazing advantage of having a computerized production system that allows them to turn around a cartoon in a matter of days (cartoons like the "Simpsons" are farmed out overseas.) This gives them the capability of being more topical than almost any other show of that type. News of the weekend can end up in Wednesday's new "South Park."