Don't have a lot to add.

Well, a little...

Its difficult to draw the line, practically, between a government (on one hand) that 'knows whats best' because it uses good science and eschews ideological or faith based dogma, and (on the other hand) a government that 'knows whats best' because its The Government (and perhaps cherry-picks or edits science accordingly- Sound familiar?).

The government has never been in the first category as long as I've been alive, with the obvious corollary that the latter category is not a monopoly of Republican administrations.

This only becomes a problem when a government is given authority over a hell of a lot of things it was never intended to have authority over, like what kind of light bulbs I use, an idiotic idea from a Master of Arts in Public Policy and Administration who probably doesn't even know how an incandescent bulb works, never mind a fluorescent one.

I would support laws requiring full disclosure of information and penalties for fraud, to allow people the maximum ability to make their own choices. As you point out, this would work for the trans-fat issue. In case nobody had noticed, a huge number of food manufacturers and restaurants are switching away from trans-fats. Look at the labels in the grocery stores. This is not something that the Great Enlightened forced on them at gunpoint. It's the market at work.

Another example where information would be more useful than regulation: If you want campaign finance laws that would actually be useful, remove all the restrictions on contributions, but demand absolute transparency on the sources and recipients. Preferably on a widely-known public internet site. Anonymous contributions, "laundered" money, or "sock puppet" activist organizations should be out of the game. If a dollar, or a million dollars, shows up in somebody's coffers, it should have a clear label on whose wallet it used to be in.

Drugs? While the ideal libertarian solution is to legalize all drugs, I am wary of most "ideal" solutions. In practice I wouldn't mind a more cautious approach. But I would certainly start by decriminalizing marijuana. A country where alcohol is legal and marijuana is not makes no sense.