Theoretically we could build interferometers the size of the solar system. What will we discover as we build ultra accurate gravitation wave detectors? Meta materials are allowing us to break wavelength resolution "limits" . The large hadron collider will be coming on line soon and will either find or not find the "god" particle. Either way it will be a fundamental advance in physics. What else will it uncover? We are starting to tease out more information about dark energy and dark matter. What will more details about these reveal about the nature of the universe. Computer technology is going to continue with Moores law for a while yet just with existing technology. Then there is the possibility of molecular computing and quantum computing. What will the abillity to simulate equations thousands or millions of times faster than we can today reveal? In mathematics computer power has allowed us to solve conjecturres that had defied human solution for hundreds of years (e.g. the four color problem). Will vast computing power unlock some of the secrets of complex theories of the universe, possible even unify relativity and quantum theory? Or maybe just reveal testable features of the theories.

I think when the idea of the end of physics was first broached we didn't even know about dark matter and energy, the stuff that makes up 95% of our CURRENTLY observable universe. Once we extend our little earth colony out into the solar system, automation and resources will allow us to construct vast machines that seem almost incocievable to us today. I don't know if we will ever see an end to physics, but certainly not for several hundred years.