re: my feelings
For most of the scientific era, we've been able to make some sense out of some limited aspects of the universe. Probably because we've evolved to survive in it, trite as that may seem. Whether we have the capacity to understand what it's all about (whatever that means) is an act of faith currently practised by most scientists. But it is just that, an act of faith. It's been pragmatic...so far.
One other point I'd like to make. Science does not claim to describe the true essence of the physical world. It does claim to have constructed the best as of yet models of physical reality, ones subject to continued tests. All subject to further enhancements and upgrades.