Oil
Assuming that we came up with alternatives for Middle Eastern oil, where do you think they would then sell it? China? Does this enhance world stability? How about if they can't sell as much anymore, and their economies collapse? Is that better or worse for terrorism?
And what about Israel? It's still a sore spot, even if we are all running on Mr. Fusion.
Reducing our dependence on oil sounds like a way to justify isolationism. I can see the attraction of it, but not sure it's possible in this day and age.